Dr.Unanue states that hydrophobia was first known in South America in 1803: this statement is corroborated by Azara and Ulloa having never heard of it in their time.

Dr.Unanue says that it broke out in Central America, and slowly travelled southward.

It reached Arequipa in 1807; and it is said that some men there, who had not been bitten, were affected, as were some negroes, who had eaten a bullock which had died of hydrophobia.

At Ica forty-two people thus miserably perished.

The disease came on between twelve and ninety days after the bite; and in those cases where it did come on, death ensued invariably within five days.