Because the Connexion between simple Ideas in substances is for the most part unknown.
This, how weighty and considerable a part soever of human science, is yet very narrow, and scarce any at all.

The reason whereof is, that the simple ideas whereof our complex ideas of substances are made up are, for the most part, such as carry with them, in their own nature, no VISIBLE NECESSARY connexion or inconsistency with any other simple ideas, whose co-existence with them we would inform ourselves about.
11.

Especially of the secondary Qualities of Bodies.
The ideas that our complex ones of substances are made up of, and about which our knowledge concerning substances is most employed, are those of their secondary qualities; which depending all (as has been shown) upon the primary qualities of their minute and insensible parts; or, if not upon them, upon something yet more remote from our comprehension; it is impossible we should know which have a NECESSARY union or inconsistency one with another.

For, not knowing the root they spring from, not knowing what size, figure, and texture of parts they are, on which depend, and from which result those qualities which make our complex idea of gold, it is impossible we should know what OTHER qualities result from, or are incompatible with, the same constitution of the insensible parts of gold; and so consequently must always co-exist with that complex idea we have of it, or else are inconsistent with it.
12.

Because necessary Connexion between any secondary and the primary Qualities is undiscoverable by us.
Besides this ignorance of the primary qualities of the insensible parts of bodies, on which depend all their secondary qualities, there is yet another and more incurable part of ignorance, which sets us more remote from a certain knowledge of the co-existence or INCO-EXISTENCE (if I may so say) of different ideas in the same subject; and that is, that there is no discoverable connexion between any secondary quality and those primary qualities which it depends on.
13.