We have no perfect knowledge of their Primary Qualities.
That the size, figure, and motion of one body should cause a change in the size, figure, and motion of another body, is not beyond our conception; the separation of the parts of one body upon the intrusion of another; and the change from rest to motion upon impulse; these and the like seem to have SOME CONNEXION one with another.

And if we knew these primary qualities of bodies, we might have reason to hope we might be able to know a great deal more of these operations of them one upon another: but our minds not being able to discover any connexion betwixt these primary qualities of bodies and the sensations that are produced in us by them, we can never be able to establish certain and undoubted rules of the CONSEQUENCE or CO-EXISTENCE of any secondary qualities, though we could discover the size, figure, or motion of those invisible parts which immediately produce them.

We are so far from knowing WHAT figure, size, or motion of parts produce a yellow colour, a sweet taste, or a sharp sound, that we can by no means conceive how ANY size, figure, or motion of any particles, can possibly produce in us the idea of any colour, taste, or sound whatsoever: there is no conceivable connexion between the one and the other.
14.

And seek in vain for certain and universal knowledge of unperceived qualities in substances.
In vain, therefore, shall we endeavour to discover by our ideas (the only true way of certain and universal knowledge) what other ideas are to be found constantly joined with that of OUR complex idea of any substance: since we neither know the real constitution of the minute parts on which their qualities do depend; nor, did we know them, could we discover any necessary connexion between them and any of the secondary qualities: which is necessary to be done before we can certainly know their necessary co-existence.

So, that, let our complex idea of any species of substances be what it will, we can hardly, from the simple ideas contained in it, certainly determine the necessary co-existence of any other quality whatsoever.