When the squadron sent against Patara achieved nothing, the new admiral Lucius Aemilius Regillus, who had arrived with 20 war-vessels from Rome and had relieved Gaius Livius at Samos, was so indignant that he proceeded thither with the whole fleet; his officers with difficulty succeeded, while they were on their voyage, in making him understand that the primary object was not the conquest of Patara but the command of the Aegean Sea, and in inducing him to return to Samos.

On the mainland of Asia Minor Seleucus had in the meanwhile begun the siege of Pergamus, while Antiochus with his chief army ravaged the Pergamene territory and the possessions of the Mytilenaeans on the mainland; they hoped to crush the hated Attalids, before Roman aid appeared.

The Roman fleet went to Elaea and the port of Adramytium to help their ally; but, as the admiral wanted troops, he accomplished nothing.

Pergamus seemed lost; but the laxity and negligence with which the siege was conducted allowed Eumenes to throw into the city Achaean auxiliaries under Diophanes, whose bold and successful sallies compelled the Gallic mercenaries, whom Antiochus had entrusted with the siege, to raise it.
In the southern waters too the projects of Antiochus were frustrated.
The fleet equipped and led by Hannibal, after having been long detained by the constant westerly winds, attempted at length to reach the Aegean; but at the mouth of the Eurymedon, off Aspendus in Pamphylia, it encountered a Rhodian squadron under Eudamus; and in the battle, which ensued between the two fleets, the excellence of the Rhodian ships and naval officers carried the victory over Hannibal's tactics and his numerical superiority.

It was the first naval battle, and the last battle against Rome, fought by the great Carthaginian.
The victorious Rhodian fleet then took its station at Patara, and there prevented the intended junction of the two Asiatic fleets.