He did this notably in the case of both Vittoria Colonna and Tommaso dei Cavalieri.

For the latter he designed subjects from Greek mythology; for the former, episodes in the Passion of our Lord.

"At the request of this lady," says Condivi, "he made a naked Christ, at the moment when, taken from the cross, our Lord would have fallen like an abandoned corpse at the feet of his most holy Mother, if two angels did not support him in their arms.

She sits below the cross with a face full of tears and sorrow, lifting both her widespread arms to heaven, while on the stem of the tree above is written this legend, 'Non vi si pensa quanto sangue costa.' The cross is of the same kind as that which was carried in procession by the White Friars at the time of the plague of 1348, and afterwards deposited in the Church of S.Croce at Florence.

He also made, for love of her, the design of a Jesus Christ upon the cross, not with the aspect of one dead, as is the common wont, but in a divine attitude, with face raised to the Father, seeming to exclaim, 'Eli! Eli!' In this drawing the body does not appear to fall, like an abandoned corpse, but as though in life to writhe and quiver with the agony it feels." Of these two designs we have several more or less satisfactory mementoes.