In 1512 Pescara was wounded and made prisoner at the battle of Ravenna, and, though he returned to his wife for a short interval, duty called him again to the field of war in Lombardy in 1515.

After this date Vittoria saw him but seldom.

The last time they met was in October 1522.

As general of the Imperial forces, Pescara spent the next years in perpetual military operations.

Under his leadership the battle of Pavia was won in 1525, and King Francis became his master's prisoner.