The bones of the face were not affected.

When standing, the patient had a peculiar bowed condition of the legs, with marked flexure at the knees.

He finally died of osteosarcoma, originating in the left radius, Paget collected eight cases, five of whom died of malignant disease.

The postmortem of Paget's case showed extreme thickening in the bones affected, the femur and cranium particularly showing osteoclerosis.

Several cases have been recorded in this country; according to Warren, Thieberge analyzed 43 cases; 21 were men, 22 women; the disease appeared usually after forty.
Acromegaly is distinguished from osteitis deformans in that it is limited to hypertrophy of the hands, feet, and face, and it usually begins earlier.