In gigantism the so-called "giant growth of bones" is often congenital in character, and is unaccompanied by inflammatory symptoms.
The deformities of the articulations may be congenital but in most cases are acquired.

When these are of extreme degree, locomotion is effected in most curious ways.

Ankylosis at unnatural angles and even complete reversion of the joints has been noticed.

Pare gives a case of reversion, and of crooked hands and feet; and Barlow speaks of a child of two and three-quarter years with kyphosis, but mobility of the lumbar region, which walked on its elbows and knees.

The pathology of this deformity is obscure, but there might have been malposition in utero.