The Duc de Mayenne died in 1611, leaving by his wife, Henriette de Savoie, daughter of the Comte de Tende, one son, Henri, who died without issue in 1621.
[206] Charles de Lorraine, Duc de Guise, born in 1571, was the son of Henri, Duc de Guise, who was assassinated at the States of Blois in 1588.

At the period of his father's death he was conveyed to the castle of Tours, where he was retained a prisoner until August 1591, when he effected his escape, a circumstance which materially changed the fortunes of the League.

The general impression in the capital had been that he would become the husband of the Infanta Isabel, the daughter of Philip II of Spain, who would cause him to be proclaimed King, an arrangement which the Duque de Feria, the Spanish ambassador, proposed to the League in 1593.

The Legate, the Sixteen, and the doctors of the Sorbonne, alike favoured this election, and the negotiations proceeded so far that the Spaniards and Neapolitans in Paris rendered him regal honours.

The young Prince, who had at this period only attained his twenty-second year, expressed great indignation at being made the puppet of so absurd a comedy, feeling convinced that neither the Duc de Mayenne nor the Duc de Nemours, both of whom coveted the crown, would finally favour his accession; and there can be little doubt that the state of extreme poverty to which he was reduced at the time caused him to consider the project as still more extravagant than he might otherwise have done, it being stated (_Mem.