On the 19th and 20th of May, 1856, he delivered an elaborate speech in the Senate, occupying two days.

It was one of his greatest efforts, and had been prepared with his usual industry.

In character it was a philippic rather than an argument, strong, direct, and aggressive, in which classical illustration and acrimonious accusation were blended with great effect.
It described what he called "The Crime against Kansas"; and the excuses for the crime he denominated the apology tyrannical, the apology imbecile, the apology absurd, and the apology infamous.
"Tyranny, imbecility, absurdity, and infamy," he continued, "all unite to dance, like the weird sisters, about this crime." In the course of his speech he alluded, among others, to A.P.

Butler, of South Carolina, and in reply to some severe strictures by that Senator during preceding debates, indulged in caustic personal criticism upon his course and utterance, as well as upon the State which he represented.
With regret [said Sumner], I come again upon the Senator from South Carolina [Mr.Butler], who, omnipresent in this debate, overflowed with rage at the simple suggestion that Kansas had applied for admission as a State; and with incoherent phrases discharged the loose expectoration of his speech, now upon her representative and then upon her people.

There was no extravagance of the ancient parliamentary debate which he did not repeat; nor was there any possible deviation from truth which he did not make, with so much of passion, I am glad to add, as to save him from the suspicion of intentional aberration.