He stood completely isolated from the other immigrants during his brief existence as a pioneer, and had his real relationship with the old English founders of the proprietary colonies, and with the more modern American land speculators, whose schemes are so often mentioned during the last half of the eighteenth century.
Episcopacy was an exotic in the backwoods; it did not take real root in Kentucky till long after that commonwealth had emerged from the pioneer stage.
When the Transylvanian Legislature dissolved, never to meet again, Henderson had nearly finished playing his short but important part in the founding of Kentucky.

He was a man of the seacoast regions, who had little in common with the backwoodsmen by whom he was surrounded; he came from a comparatively old and sober community, and he could not grapple with his new associates; in his journal he alludes to them as a set of scoundrels who scarcely believed in God or feared the devil.

A British friend[26] of his, who at this time visited the settlement, also described the pioneers as being a lawless, narrow-minded, unpolished, and utterly insubordinate set, impatient of all restraint, and relying in every difficulty upon their individual might; though he grudgingly admitted that they were frank, hospitable, energetic, daring, and possessed of much common-sense.

Of course it was hopeless to expect that such bold spirits, as they conquered the wilderness, would be content to hold it even at a small quit-rent from Henderson.

But the latter's colony was toppled over by a thrust from without before it had time to be rent in sunder by violence from within.
Transylvania was between two millstones.