From 1506 to 1515, between Louis XII.'s will and his death, we find in the history of his career in Italy five coalitions, and as many great battles, of a profoundly contradictory character.

In 1508, Pope Julius II., Louis XII., Emperor Maximilian, and Ferdinand the Catholic, King of Spain, form together against the Venetians the League of Cambrai.

In 1510, Julius II., Ferdinand, the Venetians, and the Swiss make a coalition against Louis XII.

In 1512, this coalition, decomposed for a while, re-unites, under the name of the League of the Holy Union, between the pope, the Venetians, the Swiss, and the Kings of Arragon and Naples against Louis XII., minus the Emperor Maximilian, and plus Henry VIII., King of England.

On the 14th of May, 1509, Louis XII., in the name of the League of Cambrai, gains the battle of Agnadello against the Venetians.