He urges against the poisonous effects of parties.

He warns against the evils that may arise when parties choose different foreign nations for their favorites.
The great rule of conduct for us [he says] in regard to foreign Nations is, in extending our commercial relations, to have with them as little _Political_ connection as possible.

So far as we have already formed engagements, let them be fulfilled with perfect good faith.

Here let us stop.
Europe has a set of primary interests, which to us have none, or a very remote relation.

Hence she must be engaged in frequent controversies, the causes of which are essentially foreign to our concerns.