The population was reported as 400 in 1842, and it is supposed that possibly 250 still lived at the Mission in 1845.

On May 5, 1846, Pico sold all the property to Andres Pico and J.B.Alvarado for $12,000, but the sale never went into effect.
Mission San Jose de Guadalupe and the pueblo of the same name are not, as so many people, even residents of California, think, one and the same.

The pueblo of San Jose is now the modern city of that name, the home of the State Normal School, and the starting-point for Mount Hamilton.

But Mission San Jose is a small settlement, nearly twenty miles east and north, in the foothills overlooking the southeast end of San Francisco Bay.

The Mission church has entirely disappeared, an earthquake in 1868 having completed the ruin begun by the spoliation at the time of secularization.