The reduction of the Hellespontine Greeks and of the AEolians followed.

The toils now closed around Ionia, and her cities began to be attacked one by one; whereupon the incapable Aristagoras, deserting the falling cause, betook himself to Europe, where a just Nemesis pursued him: he died by a Thracian sword.

After this the climax soon arrived.

Persia concentrated her strength upon Miletus, the cradle of the revolt, and the acknowledged chief of the cities; and though her sister states came gallantly to her aid, and a fleet was collected which made it for a while doubtful which way victory might incline, yet all was of no avail.

Laziness and insubordination began and treachery completed the work which all the force of Persia might have failed to accomplish; the combined Ionian fleet was totally defeated in the battle of Lade; and soon after Miletus herself fell.
The bulk of her inhabitants were transported into inner Asia and settled upon the Persian Gulf.