She was deaf and blind; her face often flushed, sometimes deadly cold; her hands clay-cold, often blue, and difficult to warm with the most vigorous friction.

These attacks passed off in from twenty minutes to a couple of hours.' Soon 'the attacks became more frequent, with the reappearance of another old symptom,--acute tenderness of the spine, especially over the sacrum.

Then came frequent and persistent attacks of sciatica, and gradual loss of strength.' About this time there appears to have been some uterine lesion, for a well-known gynaecologist went down to the country to see her.

Eventually 'she became unable to do anything almost for herself, for the nervous irritability had distressingly increased.
To touch her bed, the ringing of a bell, sometimes the sound of a voice, sunlight, &c., affected her so as to make her almost cry out.' 'If she stood up, or even raised her hands to dress her hair, they immediately became blue and deadly cold, and she was done for.' Then followed palpitations of a distressing character, with loud blowing murmur, and pulse of 120 to 140, for which she was seen by an eminent physician, who diagnosed them to be caused by 'slight ventricular asynchronism, with atonic condition of the cardiac as well as of all other muscles of the body.' 'She has no appetite whatever.' 'Any attempt at walking brings on sciatica.

She cannot sit, because the tip of the spine is so sensitive; any pressure on it makes her feel faint.