Their general, Malatesta Baglioni, broke his faith with the citizens.

Finally, on August 12, the town capitulated.

Alessandro de'Medici, who had received the title of Duke of Florence from Charles at Bologna, took up his residence there in July, 1531, and held the State by help of Spanish mercenaries under the command of Alessandro Vitelli.

When he was murdered by his cousin in 1537, Cosimo de'Medici, the scion of another branch of the ruling family, was appointed Duke.

Charles V.recognized his title, and Cosimo soon showed that he was determined to be master in his own duchy.