Her death was a terrible blow to the Reformed religion.

She died on the 9th of June, and the marriage was, in consequence, deferred until August.
The Admiral had not been present at Blois during the negotiations for the marriage, for after remaining there for three weeks he had retired to his estate at Chatillon, where he occupied himself with the work of restoring his ruined chateau.
The Countess Amelie had accompanied the Queen of Navarre to Blois, and also to Paris, and had been with her at the time she died.

She had sent a message to Francois and Philip to join her there, when she left Blois; accompanying her letter with a safe conduct signed by the king.

On the road they were met by the news of the death of the Queen of Navarre.

It was a severe blow to both of them, not only from the effect it would have upon the Huguenot cause, but from the affection they personally felt for her.
The king, being grievously harassed by the opposite counsels he received, and his doubts as to which of his advisers were honest, wrote to Coligny; begging him to come and aid him, with his counsel and support.
The Admiral received many letters imploring him not to go to Paris; where, even if the friendship of the king continued, he would be exposed to the danger of poison, to which, it was generally believed, his brothers and the Queen of Navarre had succumbed; but although fully aware of the danger of the step, he did not hesitate.