Cattle as a rule will avoid it, but for some unknown reason the time comes when you hear the expression the "cattle are eating loco." If so they will continue to eat it, to eat nothing else, till it is all gone; and those eating it will set the example to others, and all that have eaten it will go stark staring mad and the majority of them die.
Horses are even more liable to take to it, and are affected exactly in the same way; they go quite crazy, refuse to drink water, cannot be led, and have a dazed, stupid appearance and a tottering gait, till finally they decline and die for want of nourishment.

I have seen locoed horses taken up and fed on grain, when some of them recovered and quite got over the habit even of eating the weed; but these were exceptions.

Most locoed horses remained too stupid to do anything with and were never of much value.

There is one strange fact, however, about them; saddle horses, slightly locoed, just so bad that they cannot be led, and therefore useless as saddlers, do, when hitched up to a wagon or buggy, though never driven before, make splendid work horses.

They go like automatons; will trot if allowed till they fall down, and never balk.
The worst outlaw horse we ever had, one that had thrown all the great riders of the country and had never been mastered, this absolute devilish beast got a pretty bad dose of the weed; and, to experiment, we hitched him up in a wagon, when lo! he went off like any old steady team horse.