Calloway objected to this but the other Indians laid hold or tryed to lay hold of the other hand but Colonel Calloway was the first that jerked away from them but the Indians seized the men two Indians holt of one man or it was mostly the case and did their best to hold them but while the man and Indians was a scuffling the men from the Fort agreeable to Col.

Calloway's order fired on them they had a dreadful skuffel but our men all got in the fort safe and the fire continued on both sides." During the siege Callaway, the leader of the pioneers, made a wooden cannon wrapped with wagon tires, which on being fired at a group of Indians "made them scamper perdidiously." The secret effort of the Indians to tunnel a way underground into the fort, being discovered by the defenders, was frustrated by a countermine.

Unable to outwit, outfight, or outmaneuver the resourceful Callaway, de Quindre finally withdrew on September 16th, closing the longest and severest attack that any of the fortified stations of Kentucky had ever been called upon to withstand.
The successful defense of the Transylvania Fort, made by these indomitable backwoodsmen who were lost sight of by the Continental Congress and left to fight alone their battles in the forests, was of national significance in its results.

Had the Transylvania Fort fallen, the northern Indians in overwhelming numbers, directed by Hamilton and led by British officers, might well have swept Kentucky free of defenders and fallen with devastating force upon the exposed settlements along the western frontiers of North Carolina, Virginia, and Pennsylvania, This defense of Boonesborough, therefore, is deserving of commemoration in the annals of the Revolution, along with Lexington and Bunker's Hill.

Coupled with Clark's meteoric campaign in the Northwest and the subsequent struggles in the defense of Kentucky, it may be regarded as an event basically responsible for the retention of the trans-Alleghany region by the United States.