The time had now come for the Duke of Valentinois to continue the pursuit of his conquests.

So, since on the 1st of May in the preceding year the pope had pronounced sentence of forfeiture in full consistory against Julius Caesar of Varano, as punishment for the murder of his brother Rudolph and for the harbouring of the pope's enemies, and he had accordingly been mulcted of his fief of Camerino, which was to be handed over to the apostolic chamber, Caesar left Rome to put the sentence in execution.

Consequently, when he arrived on the frontiers of Perugia, which belonged to his lieutenant, Gian Paolo Baglioni, he sent Oliverotta da Fermo and Orsini of Gravina to lay waste the March of Camerino, at the same time petitioning Guido d'Ubaldo di Montefeltro, Duke of Urbino, to lend his soldiers and artillery to help him in this enterprise.

This the unlucky Duke of Urbino, who enjoyed the best possible relations with the pope, and who had no reason for distrusting Caesar, did not dare refuse.

But on the very same day that the Duke of Urbina's troops started for Camerino, Caesar's troops entered the duchy of Urbino, and took possession of Cagli, one of the four towns of the little State.