The poison in the form of powder was a sort of white flour, almost impalpable, with the taste of sugar, and called Contarella.

Its composition is unknown.
The liquid poison was prepared, we are told in so strange a fashion that we cannot pass it by in silence.

We repeat here what we read, and vouch for nothing ourselves, lest science should give us the lie.
A strong dose of arsenic was administered to a boar; as soon as the poison began to take effect, he was hung up by his heels; convulsions supervened, and a froth deadly and abundant ran out from his jaws; it was this froth, collected into a silver vessel and transferred into a bottle hermetically sealed, that made the liquid poison.] Towards evening Alexander VI walked from the Vatican leaning on Caesar's arm, and turned his steps towards the vineyard, accompanied by Cardinal Caraffa; but as the heat was great and the climb rather steep, the pope, when he reached the top, stopped to take breath; then putting his hand on his breast, he found that he had left in his bedroom a chain that he always wore round his neck, which suspended a gold medallion that enclosed the sacred host.

He owed this habit to a prophecy that an astrologer had made, that so long as he carried about a consecrated wafer, neither steel nor poison could take hold upon him.

Now, finding himself without his talisman, he ordered Monsignors Caraffa to hurry back at once to the Vatican, and told him in which part of his room he had left it, so that he might get it and bring it him without delay.
Then, as the walk had made him thirsty, he turned to a valet, giving signs with his hand as he did so that his messenger should make haste, and asked for something to drink.